Prader-Willi syndrome, excessive daytime sleepiness, and narcoleptic symptoms: a case report

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Prader-Willi syndrome, excessive daytime sleepiness, and narcoleptic symptoms: a case report

INTRODUCTION Sleep abnormalities, including narcolepsy and cataplexy, are a common feature of Prader-Willi syndrome. Long-term treatment with the central nervous system stimulant modafinil has not been reported. In this case report we present a longitudinal perspective of sleep abnormalities in a nine-year-old Caucasian girl with Prader-Willi syndrome from age two to age nine, and detail the re...

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An obese female with Prader-Willi syndrome and daytime sleepiness.

A obese 13-year-old female with Prader-Willi syndrome (PWS) was referred for evaluation of excessive daytime sleepiness. She was a resident of a group home for persons with PWS allowing for dietary management and a regimented schedule. Her daily wake time was 06:30 and bedtime was 21:00. The patient had a tonsillectomy and adenoidectomy at age 5 years for obstructive sleep apnea and had never b...

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Tryptophan for the treatment of excessive daytime sleepiness in Prader-Willi syndrome.

An 8-year old girl with Prader-Willi Syndrome presenting with excessive daytime sleepiness improved following treatment with tryptophan; possibly by consolidation of her fragmented sleep. Improvement was recorded on a follow-up sleep study, one year after initiating treatment with tryptophan. We conclude that tryptophan may be an useful medication for excessive sleepiness in children with Prade...

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Efficacy of modafinil on excessive daytime sleepiness in Prader-Willi syndrome.

Excessive daytime sleepiness is a frequent and a highly disruptive symptom to the daily routine of children with Prader-Willi Syndrome (PWS) and their families. The objective of the study was to evaluate the efficacy of modafinil, a central stimulant, on excessive daytime sleepiness in children and adolescents with PWS. The efficacy of modafinil was evaluated in this open label pilot study comp...

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[Prader-Willi syndrome: A case report].

A case of a male infant presenting in the neonatal period is described to highlight the morbidity of Prader-Willi. His features included marked hypotonia, feeding difficulty, hypogonadism and typically dysmorphic facies. Marked improvement in muscle tone was noted by 5 months of age. Emphasis is placed on its neonatal presentation and possible aetiologic mechanisms. The natural history is also ...

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ژورنال

عنوان ژورنال: Journal of Medical Case Reports

سال: 2014

ISSN: 1752-1947

DOI: 10.1186/1752-1947-8-127